Cyclic RGD-Containing Peptide Prevents Neointima Formation
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چکیده
Background RGD-containing peptides are able to prevent binding of ligands to certain integrins such as a!IIb3 (glycoprotein Ilb/llla) and C4a33 and as such are inhibitors for platelet aggregation and smooth muscle cell migration, both of which are involved in neointima formation. Methods and Results Hamster carotid arteries were damaged, and neointima formation was determined at different time points. G4120, a cyclic RGD-containing peptide, was administered continuously intravenously by an implanted osmotic pump. Neointima formation was inhibited dose dependently. The inhibition was strongest when treatment was started before the vascular injury and continued for the full
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تاریخ انتشار 2005